Akt also called protein kinase b because of its similarity with protein kinase a and c is a serine threonine kinase involved in the regulation of a variety of cellular functions including metabolism glucose uptake proliferation and protein synthesis all assigned toward the single goal of cell survival 3738 mammals have 3 isoforms of . The mitochondrial sirtuins sirt3 5 21 27 28 29 participate in the regulation of atp production metabolism apoptosis and cell signalingunlike the 100 kda protein sirt1 the mitochondrial sirtuins are small ranging from 30 40 kda thus their amino acid sequence consists mostly of an n terminal mitochondrial targeting sequence and the sirtuin core domain with small flanking regions. Sirtuins are nad dependent histone deacetylases class iii hdacs recently sirtuins have been shown to play important roles both direct and indirect in transcriptional regulation this transcriptional control through incorporation of sirtuins into transcription complexes and deacetylation of
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