Defective migration of t cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy the volume includes three sections the first section covers general knowledge about t cell trafficking during a normal immune response but also during tumor development. This volume focuses on recent advances in understanding t cells as key players in antitumor immune responses and as a result t cell based immunotherapy is starting to transform the treatment of . Defects in t cell trafficking and resistance to cancer immunotherapy resistance to targeted anti cancer therapeutics keystone symposia scientific conferences on biomedical keystone symposia a non. In some cases targeted therapies can enhance aspects of cancer immunity such as tumor antigenicity t cell trafficking or t cell infiltration into tumors which provides a rationale for combining them with checkpoint inhibitors or other cancer immunotherapies that may lead to synergistic efficacy. An additional cancer cell intrinsic mechanism of primary resistance to immunotherapy is expression of a certain set of genes that were found to be enriched in tumors from patients who did not respond to anti pd 1 therapy termed innate anti pd 1 resistance signature or ipres
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